Medicinos teorija ir praktika 2012 m. 18 tomas Nr. 4.2
ŠLAPIMO TAKŲ INFEKCIJOS RIZIKOS FAKTORIAI ANKSTYVUOJU LAIKOTARPIU PO INKSTŲ TRANSPLANTACIJOS IR JŲ ĮTAKA INKSTŲ TRANSPLANTŲ BEI PACIENTŲ IŠGYVENAMUMUI
Laurynas Rimševičius, Ana Chalkovskaja, Ilona Rudminienė, Sigita Anisko, Kastė Mateikaitė, Karolis Skebas, Agnė Laučytė, Aldona Stanevičienė, Tatjana Rainienė, Vytautas Razukas, Marius Miglinas
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Key words: renal transplantation, urinary tract infection, long-term survival.
Acute urinary tract infection (UTI) is the most common complication after renal transplantation. Although some data show that it influences graft and patient survival in children and in adult, we still lack assurance about its impact on long-term outcomes. Also, there are different opinions about risk factors that cause UTI. A retrospective cohort study was performed. We evaluated data of 408 recipients from single transplantation centre and identified risk factors that cause occurrence of UTI during first 3 months after transplantation. Secondary outcome of our study was to assess UTIs’ impact on graft and patient survival. Our analysis confirmed that female gender (female 59% vs. 33% ) and elder age (42.23 ± 12.17 vs. 39.07±10.79) at the time of transplantation are independent risk factors, associated with risk to develop acute UTI in the early post-transplant period. Induction therapy with monoclonal antibodies reduced rate of UTI (daclizumab group 46 vs. 74).Other factors such as type and duration of dialysis, diabetes, delayed graft function and cold ischemia time did not affect occurrence of UTI. Acute UTI in first 3 months after transplantation predicted significantly shorter survival of patients in 10 years (83% vs. 51%), but not graft survival (65% vs. 50%). Our future interest is late UTI and its relation to outcomes of transplantation.